Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia
نویسندگان
چکیده
منابع مشابه
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
Resistance to quinolones in Gram-negative bacteria is usually mediated by the following: (i) chromosomal mutations that alter the target enzymes, DNA gyrase and topoisomerase IV, in their quinolone resistance-determining regions (QRDR), (ii) changes in drug entry (loss of porin channels), and (iii) the presence of plasmid-mediated quinolone resistance (PMQR) determinants [qnrA, qnrB, qnrS, qnrC...
متن کاملCitrobacter spp. as a source of qnrB Alleles.
qnrB is the most common of the five qnr families and has the greatest number of allelic variants. Almost two-thirds of the qnrB alleles have been reported in Citrobacter spp., and several were shown to be located on the chromosome. In this study, PCR was used to investigate the prevalence of plasmid-mediated quinolone resistance genes in 71 clinical isolates belonging to the Citrobacter freundi...
متن کاملNovel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii.
Three epidemiologically and clonally unrelated Citrobacter werkmanii isolates of poultry origin from Germany (Table 1) were investigated for the mechanisms responsible for decreased fluoroquinolone susceptibility. The MICs, determined by broth macrodilution (10), varied between 8 and 256 g/ml for nalidixic acid and between 0.0625 and 1 g/ml for ciprofloxacin (Table 1). CIT2 was additionally res...
متن کاملHigh Prevalence of qnr and aac(6′)-Ib-cr Genes in Both Water-Borne Environmental Bacteria and Clinical Isolates of Citrobacter freundii in China
We investigated the prevalence of qnr and aac(6')-Ib-cr genes in water-borne environmental bacteria and in clinical isolates of Enterobacteriaceae, as well as the subtypes of qnr. Environmental bacteria were isolated from surface water samples obtained from 10 different locations in Hangzhou City, and clinical isolates of Citrobacter freundii were isolated from several hospitals in four cities ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2009
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.2009.02744.x